The Future of Radiobiology

David G Kirsch; Max Diehn; Aparna H Kesarwala; Amit Maity; Meredith A Morgan; Julie K Schwarz; Robert Bristow; Sandra Demaria; Iris Eke; Robert J Griffin; Daphne Haas-Kogan; Geoff S Higgins; Alec C Kimmelman; Randall J Kimple; Isabelle M Lombaert; Li Ma; Brian Marples; Frank Pajonk; Catherine C Park; Dörthe Schaue; Phuoc T Tran; Henning Willers; Brad G Wouters; Eric J Bernhard

doi:10.1093/jnci/djx231

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The Future of Radiobiology

David G Kirsch, Max Diehn, Aparna H Kesarwala, Amit Maity, Meredith A Morgan, Julie K Schwarz, Robert Bristow, Sandra Demaria, Iris Eke, Robert J Griffin, …

JNCI : Journal of the National Cancer Institute, Vol.110(4), pp.329-340

2018-04-01

DOI: https://doi.org/10.1093/jnci/djx231

PMCID: PMC5928778

PMID: 29126306

Abstract

Animals

Biomedical Research

Humans

Neoplasms - radiotherapy

Radiobiology

Signal Transduction

Innovation and progress in radiation oncology depend on discovery and insights realized through research in radiation biology. Radiobiology research has led to fundamental scientific insights, from the discovery of stem/progenitor cells to the definition of signal transduction pathways activated by ionizing radiation that are now recognized as integral to the DNA damage response (DDR). Radiobiological discoveries are guiding clinical trials that test radiation therapy combined with inhibitors of the DDR kinases DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM), ataxia telangiectasia related (ATR), and immune or cell cycle checkpoint inhibitors. To maintain scientific and clinical relevance, the field of radiation biology must overcome challenges in research workforce, training, and funding. The National Cancer Institute convened a workshop to discuss the role of radiobiology research and radiation biologists in the future scientific enterprise. Here, we review the discussions of current radiation oncology research approaches and areas of scientific focus considered important for rapid progress in radiation sciences and the continued contribution of radiobiology to radiation oncology and the broader biomedical research community.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.152 Molecular & Cell Biology - DNA Damage; 1.152.257 DSBs
Web Of Science research areas: Oncology
ESI research areas: Clinical Medicine

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Title: The Future of Radiobiology
Creators: David G Kirsch - Department of Radiation Oncology and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC
Max Diehn - Department of Radiation Oncology, Stanford Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA
Aparna H Kesarwala - Radiation Oncology Branch, National Institutes of Health, Bethesda, MD
Amit Maity - Department of Radiation Oncology Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Meredith A Morgan - Department of Radiation Oncology, University of Michigan, Ann Arbor, MI
Julie K Schwarz - Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO
Robert Bristow - Department of Radiation Oncology, Princess Margaret Cancer Center, Toronto, ON, Canada
Sandra Demaria - Department of Radiation Oncology and Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY
Iris Eke - Radiation Oncology Branch, National Institutes of Health, Bethesda, MD
Robert J Griffin - Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR
Daphne Haas-Kogan - Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston Children's Hospital, Boston, MA
Geoff S Higgins - Department of Oncology, University of Oxford, Oxford, Oxfordshire, UK
Alec C Kimmelman - Perlmutter Cancer Center and Department of Radiation Oncology, New York University Langone Medical Center, New York, NY
Randall J Kimple - Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI
Isabelle M Lombaert - Department of Biologic and Materials Sciences, Biointerfaces Institute, School of Dentistry, University of Michigan, Ann Arbor, MI
Li Ma - Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Brian Marples - Department of Radiation Oncology, University of Miami, Miami, FL
Frank Pajonk - Department of Radiation Oncology, University of California, Los Angeles, CA
Catherine C Park - Department of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA
Dörthe Schaue - Division of Molecular and Cellular Oncology, University of California, Los Angeles, CA
Phuoc T Tran
Henning Willers
Brad G Wouters
Eric J Bernhard - Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD
Publication Details: JNCI : Journal of the National Cancer Institute, Vol.110(4), pp.329-340
Grant note: R01 CA181029 / NCI NIH HHS R01 CA191234 / NCI NIH HHS R01 CA200234 / NCI NIH HHS P50 CA211015 / NCI NIH HHS R01 CA181745 / NCI NIH HHS R01 DE027034 / NIDCR NIH HHS R00 DE022557 / NIDCR NIH HHS R01 CA166348 / NCI NIH HHS
Language: English
Resource Type: Journal article
PMID: 29126306
PMCID: PMC5928778
Record Identifier: 991031614095502976