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The High-Mobility Group Box-1 Nuclear Factor Mediates Retinal Injury after Ischemia Reperfusion
Journal article   Open access  Peer reviewed

The High-Mobility Group Box-1 Nuclear Factor Mediates Retinal Injury after Ischemia Reperfusion

Galina Dvoriantchikova, Eleut Hernandez, Jeff Grant, Andrea Rachelle C Santos, Huan Yang and Dmitry Ivanov
Investigative ophthalmology & visual science, Vol.52(10), pp.7187-7194
2011-09
PMCID: PMC3207720
PMID: 21828158

Abstract

Hmgb1 binds with high affinity to Rage that triggers inflammation and damage. Our results suggest that an increased level of Hmgb1 and signaling via Rage contribute to neurotoxicity following retinal ischemia.
url
https://doi.org/10.1167/iovs.11-7793View
Published (Version of record) Open

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.54 Molecular & Cell Biology - Genetics
1.54.958 HMGB1
Web Of Science research areas
Ophthalmology
ESI research areas
Clinical Medicine

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#3 Good Health and Well-Being

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