Abstract
Different tail‐engineered resorcinarenes have been examined for insulin fibrillation by experimental and computational studies. The resorcinarene showed a promising effect on the inhibition of insulin fibrillation, studied using a ThT assay, circular dichroism spectroscopy, and atomic force microscopy. Both the ThT assay and computational results indicate the tail from the resorcinarene has an impact on insulin fibrillation by either inhibition or promotion because of the resident position on insulin. These observations have significant biological implications in the design of drug molecules as well as the development of potential therapeutic strategies.
The length makes all the difference: The effect of tails on resorcinarene on the insulin fibrillation process have been investigated. Whereas the shorter tails assist in inhibiting the fibrillation step, longer tails do not.
