The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Deanne Taylor; Bruce J. Aronow; Kai Tan; Kathrin M. Bernt; Nathan Salomonis; Casey S. Greene; Alina Frolova; Sarah E. Henrickson; Andrew D. Wells; Liming Pei; Jyoti K. Jaiswal; Jeffrey A. Whitsett; Kathryn E. Hamilton; Sonya A. MacParland; Judith R. Kelsen; Robert O. Heuckeroth; S. Steven Potter; Laura A. Vella; Natalie A. Terry; Louis R. Ghanem; Benjamin C. Kennedy; Ingo Helbig; Kathleen E. Sullivan; Leslie Castelo-Soccio; Arnold Kreigstein; Florian Herse; Martijn C. Nawijn; Gerard H. Koppelman; Melissa A. Haendel; Nomi L. Harris; Jo Lynne Rokita; Yuanchao Zhang; Aviv Regev; Orit Rozenblatt-Rosen; Jennifer Rood; Timothy L. Tickle; Roser Vento-Tormo; Saif Alimohamed; Monkol Lek; Jessica C. Mar; Kathleen M. Loomes; David M. Barrett; Prech Uapinyoying; Alan H. Beggs; Pankaj B. Agrawal; Yi-Wen Chen; Amanda B. Muir; Lana X. Garmire; Scott B. Snapper; Javad Nazarian; Steven H. Seeholzer; Hossein Fazelinia; Larry N. Singh; Robert B. Faryabi; Pichai Raman; Noor Dawany; Hongbo Michael Xie; Batsal Devkota; Sharon J. Diskin; Stewart A. Anderson; Eric F. Rappaport; William H. Peranteau; Kathryn A. Wikenheiser-Brokamp; Sarah A. Teichmann; Douglas C. Wallace; Tao Peng; Yang-Yang Ding; Man S. Kim; Yi Xing; Sek Won Kong; Carsten G. Bönnemann; Kenneth D. Mandl; Peter White

doi:10.1016/j.devcel.2019.03.001

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The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Journal article

Open access

Peer reviewed

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Deanne Taylor, Bruce J. Aronow, Kai Tan, Kathrin M. Bernt, Nathan Salomonis, Casey S. Greene, Alina Frolova, Sarah E. Henrickson, Andrew D. Wells, Liming Pei, …

Developmental cell, Vol.49(1), pp.10-29

2019

DOI: https://doi.org/10.1016/j.devcel.2019.03.001

Abstract

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

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https://pure.rug.nl/ws/files/81070237/1_s2.0_S1534580719301789_main.pdfView

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https://espace.library.uq.edu.au/view/UQ:770a738View

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616346/View

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.54 Molecular & Cell Biology - Genetics; 1.54.1543 RNA-Seq
Web Of Science research areas: Cell Biology; Developmental Biology
ESI research areas: Molecular Biology & Genetics

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Title: The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
Creators: Deanne Taylor - Children's Hospital of Philadelphia
Bruce J. Aronow - Cincinnati Children's Hospital Medical Center
Kai Tan - Children's Hospital of Philadelphia
Kathrin M. Bernt - Children's Hospital of Philadelphia
Nathan Salomonis - Cincinnati Children's Hospital Medical Center
Casey S. Greene - Translational Therapeutics
Alina Frolova - Institute of Molecular Biology and Genetics
Sarah E. Henrickson - Children's Hospital of Philadelphia
Andrew D. Wells - University of Pennsylvania
Liming Pei - Children's Hospital of Philadelphia
Jyoti K. Jaiswal - George Washington University
Jeffrey A. Whitsett - Cincinnati Children's Hospital Medical Center
Kathryn E. Hamilton - Children's Hospital of Philadelphia
Sonya A. MacParland - Toronto General Hospital
Judith R. Kelsen - Children's Hospital of Philadelphia
Robert O. Heuckeroth - Translational Therapeutics
S. Steven Potter - Cincinnati Children's Hospital Medical Center
Laura A. Vella - Children's Hospital of Philadelphia
Natalie A. Terry - Children's Hospital of Philadelphia
Louis R. Ghanem - Children's Hospital of Philadelphia
Benjamin C. Kennedy - Children's Hospital of Philadelphia
Ingo Helbig - Children's Hospital of Philadelphia
Kathleen E. Sullivan - Children's Hospital of Philadelphia
Leslie Castelo-Soccio - Children's Hospital of Philadelphia
Arnold Kreigstein - University of California, San Francisco
Florian Herse - Max Delbrück Center for Molecular Medicine
Martijn C. Nawijn - University Medical Center Groningen
Gerard H. Koppelman - University Medical Center Groningen
Melissa A. Haendel - Oregon Health & Science University
Nomi L. Harris - Lawrence Berkeley National Laboratory
Jo Lynne Rokita - Children's Hospital of Philadelphia
Yuanchao Zhang - Rutgers, The State University of New Jersey
Aviv Regev - Broad Institute
Orit Rozenblatt-Rosen - Broad Institute
Jennifer Rood - Broad Institute
Timothy L. Tickle - Broad Institute
Roser Vento-Tormo - Wellcome Sanger Institute
Saif Alimohamed - Cincinnati Children's Hospital Medical Center
Monkol Lek - Yale University
Jessica C. Mar - University of Queensland
Kathleen M. Loomes - Children's Hospital of Philadelphia
David M. Barrett - Children's Hospital of Philadelphia
Prech Uapinyoying - National Institute of Neurological Disorders and Stroke
Alan H. Beggs - Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Pankaj B. Agrawal - Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Yi-Wen Chen - George Washington University
Amanda B. Muir - Children's Hospital of Philadelphia
Lana X. Garmire - University of Michigan–Ann Arbor
Scott B. Snapper - Harvard University
Javad Nazarian - George Washington University
Steven H. Seeholzer - Children's Hospital of Philadelphia
Hossein Fazelinia - Children's Hospital of Philadelphia
Larry N. Singh - Children's Hospital of Philadelphia
Robert B. Faryabi - University of Pennsylvania
Pichai Raman - Children's Hospital of Philadelphia
Noor Dawany - Children's Hospital of Philadelphia
Hongbo Michael Xie - Children's Hospital of Philadelphia
Batsal Devkota - Children's Hospital of Philadelphia
Sharon J. Diskin - Children's Hospital of Philadelphia
Stewart A. Anderson - Children's Hospital of Philadelphia
Eric F. Rappaport - Children's Hospital of Philadelphia
William H. Peranteau - Children's Hospital of Philadelphia
Kathryn A. Wikenheiser-Brokamp - Cincinnati Children's Hospital Medical Center
Sarah A. Teichmann - Wellcome Sanger Institute
Douglas C. Wallace - Children's Hospital of Philadelphia
Tao Peng - Children's Hospital of Philadelphia
Yang-Yang Ding
Man S. Kim - Children's Hospital of Philadelphia
Yi Xing - Children's Hospital of Philadelphia
Sek Won Kong - Boston Children's Hospital
Carsten G. Bönnemann - National Institute of Neurological Disorders and Stroke
Kenneth D. Mandl - Boston Children's Hospital
Peter White - Cincinnati Children's Hospital Medical Center
Publication Details: Developmental cell, Vol.49(1), pp.10-29
Publisher: Elsevier BV; United States
Academic Unit: Miller School of Medicine; UMMG Dept of Pediatrics - Neonatology; UMMG Department of Pediatrics
Resource Type: Journal article
Record Identifier: 991031926786702976