The TRIM5α Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge

Matthew R Reynolds; Jonah B Sacha; Andrea M Weiler; Gretta J Borchardt; Chrystal E Glidden; Neil C Sheppard; Francesca A Norante; Philip A Castrovinci; Jacqueline J Harris; Henry T Robertson; Thomas C Friedrich; Adrian B McDermott; Nancy A Wilson; David B Allison; Wayne C Koff; Welkin E Johnson; David I Watkins

doi:10.1128/JVI.05074-11

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The TRIM5α Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge

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The TRIM5α Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge

Matthew R Reynolds, Jonah B Sacha, Andrea M Weiler, Gretta J Borchardt, Chrystal E Glidden, Neil C Sheppard, Francesca A Norante, Philip A Castrovinci, Jacqueline J Harris, Henry T Robertson, …

Journal of virology, Vol.85(18), pp.9637-9640

Notes

2011-09

DOI: https://doi.org/10.1128/JVI.05074-11

PMCID: PMC3165772

PMID: 21734037

Abstract

Virus-Cell Interactions

It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing the TRIM5 TFP and TRIM5 CypA alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing other TRIM5 allele combinations. Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses.

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Collaboration types: Industry collaboration; Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Virology
ESI research areas: Microbiology

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Title: The TRIM5α Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge
Creators: Matthew R Reynolds - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
Jonah B Sacha - Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 NW 185th Ave., Beaverton, Oregon 97006
Andrea M Weiler - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
Gretta J Borchardt - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
Chrystal E Glidden - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
Neil C Sheppard - Vaccine Research, Worldwide Research and Development, Pfizer Inc., 10777 Science Center Drive, San Diego, California 92121
Francesca A Norante - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
Philip A Castrovinci - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
Jacqueline J Harris - Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294
Henry T Robertson - Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294
Thomas C Friedrich - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
Adrian B McDermott - International AIDS Vaccine Initiative, New York, New York 10038
Nancy A Wilson - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
David B Allison - Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294
Wayne C Koff - International AIDS Vaccine Initiative, New York, New York 10038
Welkin E Johnson - New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts
David I Watkins - AIDS Vaccine Research Laboratory, 555 Science Dr., Madison, Wisconsin 53711
Publication Details: Journal of virology, Vol.85(18), pp.9637-9640
Series: Notes
Publisher: American Society for Microbiology
Academic Unit: UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 21734037
PMCID: PMC3165772
Record Identifier: 991031598128602976