The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Jane M Simoni; David Huh; Yan Wang; Ira B Wilson; Nancy R Reynolds; Robert H Remien; Kathy Goggin; Robert Gross; Marc I Rosen; Neil Schneiderman; Julia Arnsten; Carol E Golin; Judith A Erlen; David R Bangsberg; Honghu Liu

doi:10.1007/s10461-014-0905-x

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The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Journal article

Open access

Peer reviewed

The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Jane M Simoni, David Huh, Yan Wang, Ira B Wilson, Nancy R Reynolds, Robert H Remien, Kathy Goggin, Robert Gross, Marc I Rosen, Neil Schneiderman, …

AIDS and behavior, Vol.18(12), pp.2285-2290

2014-12

DOI: https://doi.org/10.1007/s10461-014-0905-x

PMCID: PMC4495040

PMID: 25280447

Abstract

AIDS

HIV

Medication adherence assessment

Social desirability

Intervention studies

In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher’s aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multisite Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [ 1 ], electronically monitored adherence and [ 2 ] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.11 HIV Prevalence & Prophylaxis
Web Of Science research areas: Public, Environmental & Occupational Health; Social Sciences, Biomedical
ESI research areas: Psychiatry/Psychology

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Title: The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study
Creators: Jane M Simoni - Department of Psychology, University of Washington, Box 351525, Seattle, WA 98195, USA
David Huh - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
Yan Wang - Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA, USA
Ira B Wilson - Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA
Nancy R Reynolds - School of Nursing, Yale University, New Haven, CT, USA
Robert H Remien - HIV Center for Clinical and Behavioral Studies, NY State Psychiatric Institute and Columbia University, New York, NY, USA
Kathy Goggin - Health Services and Outcomes Research, Children’s Mercy Hospitals and Clinics, University of Missouri-Kansas City Schools of Medicine and Pharmacy, Kansas City, MO, USA
Robert Gross - Departments of Medicine (Infectious Diseases) and Biostatistics & Epidemiology, University of Pennsylvania Perelman School of Medicine and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
Marc I Rosen - VA Connecticut Healthcare System and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Neil Schneiderman - Department of Psychology, University of Miami, Coral Gables, FL, USA
Julia Arnsten - Departments of Medicine, Psychiatry, and Epidemiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
Carol E Golin - School of Medicine, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Judith A Erlen - Department of Health and Community Systems, School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA
David R Bangsberg - Harvard Medical School, Harvard School of Public Health and Massachusetts General Hospital, Boston, USA
Honghu Liu - Division of Public Health and Community Dentistry, School of Dentistry, David Geffen School of Medicine, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA, USA
Publication Details: AIDS and behavior, Vol.18(12), pp.2285-2290
Academic Unit: College of A&S; A&S - Psychology
Language: English
Resource Type: Journal article
PMID: 25280447
PMCID: PMC4495040
Record Identifier: 991031559702102976