The importance of considering competing risks in recurrence analysis of intracranial meningioma

Christian Mirian; Lasse Rehné Jensen; Tareq A Juratli; Andrea Daniela Maier; Sverre H Torp; Helen A Shih; Ramin A Morshed; Jacob S Young; Stephen T Magill; Luca Bertero; Walter Stummer; Dorothee Cäcilia Spille; Benjamin Brokinkel; Soichi Oya; Satoru Miyawaki; Nobuhito Saito; Martin Proescholdt; Yasuhiro Kuroi; Konstantinos Gousias; Matthias Simon; Jennifer Moliterno; Ricardo Prat-Acin; Stéphane Goutagny; Vikram C Prabhu; John T Tsiang; Johannes Wach; Erdem Güresir; Junkoh Yamamoto; Young Zoon Kim; Joo Ho Lee; Matthew Koshy; Karthikeyan Perumal; Mustafa K Baskaya; Donald M Cannon; Dennis C Shrieve; Chang-Ok Suh; Jong Hee Chang; Maria Kamenova; Sven Straumann; Jehuda Soleman; Ilker Y Eyüpoglu; Tony Catalan; Austin Lui; Philip V Theodosopoulos; Michael W McDermott; Fang Wang; Fuyou Guo; Pedro Góes; Manoel Antonio de Paiva Neto; Aria Jamshidi; Ricardo Komotar; Michael Ivan; Evan Luther; Luis Souhami; Marie-Christine Guiot; Tamás Csonka; Toshiki Endo; Olivia Claire Barrett; Randy Jensen; Tejpal Gupta; Akash J Patel; Tiemo J Klisch; Jun Won Kim; Francesco Maiuri; Valeria Barresi; María Dolores Tabernero; Simon Skyrman; Anders Broechner; Mathias Jacobsen Bach; Ian Law; David Scheie; Bjarne Winther Kristensen; Tina Nørgaard Munch; Torstein Meling; Kåre Fugleholm; Paul Blanche; Tiit Mathiesen

The importance of considering competing risks in recurrence analysis of intracranial meningioma

Journal article

Peer reviewed

The importance of considering competing risks in recurrence analysis of intracranial meningioma

Christian Mirian, Lasse Rehné Jensen, Tareq A Juratli, Andrea Daniela Maier, Sverre H Torp, Helen A Shih, Ramin A Morshed, Jacob S Young, Stephen T Magill, Luca Bertero, …

Journal of neuro-oncology

2024-02-10

PMID: 38336917

Appears in Miller School of Medicine - Latest Publications

Abstract

Recurrence

Competing risk

Neuro-oncology

Meningioma

The risk of recurrence is overestimated by the Kaplan-Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided by using the Aalen-Johansen method, which is a direct extension of Kaplan-Meier that accounts for competing events. Meningiomas commonly occur in older individuals and have slow-growing properties, thereby warranting competing risk analysis. The extent to which competing events are considered in meningioma literature is unknown, and the consequences of using incorrect methodologies in meningioma recurrence risk analysis have not been investigated. We surveyed articles indexed on PubMed since 2020 to assess the usage of competing risk analysis in recent meningioma literature. To compare recurrence risk estimates obtained through Kaplan-Meier and Aalen-Johansen methods, we applied our international database comprising ~ 8,000 patients with a primary meningioma collected from 42 institutions. Of 513 articles, 169 were eligible for full-text screening. There were 6,537 eligible cases from our PERNS database. The discrepancy between the results obtained by Kaplan-Meier and Aalen-Johansen was negligible among low-grade lesions and younger individuals. The discrepancy increased substantially in the patient groups associated with higher rates of competing events (older patients with high-grade lesions). The importance of considering competing events in recurrence risk analysis is poorly recognized as only 6% of the studies we surveyed employed Aalen-Johansen analyses. Consequently, most of the previous literature has overestimated the risk of recurrence. The overestimation was negligible for studies involving low-grade lesions in younger individuals; however, overestimation might have been substantial for studies on high-grade lesions.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.113 Brain Imaging; 1.113.1562 Meningioma
Web Of Science research areas: Clinical Neurology; Oncology
ESI research areas: Neuroscience & Behavior

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Details

Title: The importance of considering competing risks in recurrence analysis of intracranial meningioma
Creators: Christian Mirian - Copenhagen University Hospital
Lasse Rehné Jensen - Copenhagen University Hospital
Tareq A Juratli - Harvard Medical School
Andrea Daniela Maier - Copenhagen University Hospital
Sverre H Torp - Department of Pathology, Laboratory Centre, St. Olavs Hospital, NO-7030, Trondheim, Norway
Helen A Shih - Harvard Medical School
Ramin A Morshed - University of California, San Francisco
Jacob S Young - University of California, San Francisco
Stephen T Magill - Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Illinois, USA
Luca Bertero - Pathology Unit, Department of Medical Sciences, University and Città Della Salute E Della Scienza University Hospital of Turin, Turin, Italy
Walter Stummer - University of Münster
Dorothee Cäcilia Spille - University of Münster
Benjamin Brokinkel - University of Münster
Soichi Oya - Department of Neurosurgery, Saitama Medical Center/University, Saitama, Japan
Satoru Miyawaki - University of Tokyo Hospital
Nobuhito Saito - University of Tokyo Hospital
Martin Proescholdt - University of Regensburg
Yasuhiro Kuroi - Tokyo Women's Medical University
Konstantinos Gousias - Athens Medical Center
Matthias Simon - Department of Neurosurgery, Bethel Clinic University of Bielefeld Medical Center, Bielefeld, Germany
Jennifer Moliterno - Yale New Haven Hospital
Ricardo Prat-Acin - Department of Neurosurgery, Hospital La Fe, Valencia, Spain
Stéphane Goutagny - Department of Neurosurgery, Université Paris Cité, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, Paris, France
Vikram C Prabhu - Loyola University Medical Center
John T Tsiang - Loyola University Medical Center
Johannes Wach - University Hospital Leipzig
Erdem Güresir - University Hospital Leipzig
Junkoh Yamamoto - Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan
Young Zoon Kim - Sungkyunkwan University
Joo Ho Lee - Seoul National University Hospital
Matthew Koshy - University of Illinois Urbana-Champaign
Karthikeyan Perumal - University of Wisconsin School of Medicine and Public Health
Mustafa K Baskaya - University of Wisconsin School of Medicine and Public Health
Donald M Cannon - University of Utah
Dennis C Shrieve - University of Utah
Chang-Ok Suh - Yonsei University
Jong Hee Chang - Yonsei University
Maria Kamenova - University Hospital of Basel
Sven Straumann - University Hospital of Basel
Jehuda Soleman - University Hospital of Basel
Ilker Y Eyüpoglu - University Hospital Carl Gustav Carus
Tony Catalan - University of California, San Francisco
Austin Lui - University of California, San Francisco
Philip V Theodosopoulos - University of California, San Francisco
Michael W McDermott - Neuroscience Institute
Fang Wang - First Affiliated Hospital of Zhengzhou University
Fuyou Guo - First Affiliated Hospital of Zhengzhou University
Pedro Góes - University of Sao Paulo
Manoel Antonio de Paiva Neto - University of Sao Paulo
Aria Jamshidi - University of Miami
Ricardo Komotar - University of Miami
Michael Ivan - University of Miami
Evan Luther - University of Miami
Luis Souhami - McGill University Health Centre
Marie-Christine Guiot - McGill University Health Centre
Tamás Csonka - University of Debrecen
Toshiki Endo - Tohoku Medical and Pharmaceutical University
Olivia Claire Barrett - Infirmary Cancer Care, Montgomery, AL, USA
Randy Jensen - Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
Tejpal Gupta - Tata Memorial Hospital
Akash J Patel - Neurological Research Institute
Tiemo J Klisch - Baylor College of Medicine
Jun Won Kim - Yonsei University
Francesco Maiuri - University of Naples Federico II
Valeria Barresi - University of Verona
María Dolores Tabernero - Instituto de Investigación Biomédica de Salamanca (IBSAL), University Hospital of Salamanca, Salamanca, Spain
Simon Skyrman - Karolinska Institutet
Anders Broechner - Copenhagen University Hospital
Mathias Jacobsen Bach - Copenhagen University Hospital
Ian Law - University of Copenhagen
David Scheie - Copenhagen University Hospital
Bjarne Winther Kristensen - University of Copenhagen
Tina Nørgaard Munch - Statens Serum Institut
Torstein Meling - Neurological Surgery
Kåre Fugleholm - University of Copenhagen
Paul Blanche - University of Copenhagen
Tiit Mathiesen - University of Copenhagen
Publication Details: Journal of neuro-oncology
Academic Unit: UMMG Dept of Neurological Surgery; Miller School of Medicine
Language: English
Resource Type: Journal article
PMID: 38336917
Record Identifier: 991031996697202976