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Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2
Journal article   Peer reviewed

Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2

J E Zengel and K L Magleby
Science (American Association for the Advancement of Science), Vol.197(4298), pp.67-69
1977-07-01
DOI: https://doi.org/10.1126/science.17160
PMID: 17160

Abstract

Calcium - pharmacology Electric Stimulation Neuromuscular Junction - drug effects Neuromuscular Junction - metabolism Neurotransmitter Agents - metabolism Rana pipiens Barium - pharmacology Motor Endplate - physiology Magnesium - pharmacology Anura Animals Membrane Potentials Strontium - pharmacology Time Factors
The addition of Sr2+ or Ba2+ to the solution bathing the frog neuromuscular junction leads to an increased release of transmitter by each nerve impulse during and following repetitive stimulation. The mechanisms by which Sr2+ and Ba2+ increase release are not the same. Each ion appears to act selectively on a different process involved in transmitter release.

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