Transplantation: platform to study recurrence of disease

George William Burke; Alla Mitrofanova; Antonio Miguel Fontanella; Francesco Vendrame; Gaetano Ciancio; Rodrigo M. Vianna; David Roth; Phillip Ruiz; Carolyn L. Abitbol; Jayanthi Chandar; Sandra Merscher; Alberto Pugliese; Alessia Fornoni

doi:10.3389/fimmu.2024.1354101

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Transplantation: platform to study recurrence of disease

Journal article

Peer reviewed

Transplantation: platform to study recurrence of disease

George William Burke, Alla Mitrofanova, Antonio Miguel Fontanella, Francesco Vendrame, Gaetano Ciancio, Rodrigo M. Vianna, David Roth, Phillip Ruiz, Carolyn L. Abitbol, Jayanthi Chandar, …

Frontiers in immunology, Vol.15

2024-03-01

DOI: https://doi.org/10.3389/fimmu.2024.1354101

Appears in Miller School of Medicine - Latest Publications

Abstract

cytokines

kidney transplant

liver transplant

pancreas transplant

recurrent disease

Beyond the direct benefit that a transplanted organ provides to an individual recipient, the study of the transplant process has the potential to create a better understanding of the pathogenesis, etiology, progression and possible therapy for recurrence of disease after transplantation while at the same time providing insight into the original disease. Specific examples of this include: 1) recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation, 2) recurrent autoimmunity after pancreas transplantation, and 3) recurrence of disease after orthotopic liver transplantation (OLT) for cirrhosis related to progressive steatosis secondary to jejuno-ileal bypass (JIB) surgery. Our team has been studying these phenomena and their immunologic underpinnings, and we suggest that expanding the concept to other pathologic processes and/or transplanted organs that harbor the risk for recurrent disease may provide novel insight into the pathogenesis of a host of other disease processes that lead to organ failure.

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Details

Title: Transplantation: platform to study recurrence of disease
Creators: George William Burke - Division of Kidney-Pancreas Transplantation, Department of Surgery, Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL, United States
Alla Mitrofanova - Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States
Antonio Miguel Fontanella - University of Miami Miller School of Medicine (United States, Miami)
Francesco Vendrame - Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States
Gaetano Ciancio - Division of Kidney-Pancreas Transplantation, Department of Surgery, Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL, United States
Rodrigo M. Vianna - University of Miami Miller School of Medicine (United States, Miami)
David Roth - University of Miami Miller School of Medicine (United States, Miami)
Phillip Ruiz - Transplant Pathology, Immunology and Histocompatibility Laboratory University of Miami Department of Surgery, Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL, United States
Carolyn L. Abitbol - Pediatric Nephrology & Hypertension, University of Miami Miller School of Medicine, Miami, FL, United States
Jayanthi Chandar - University of Miami Miller School of Medicine (United States, Miami)
Sandra Merscher - Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States
Sandra Merscher - Peggy and Harold Katz Family Drug Discovery Center, Department of Medicine, University of Miami - Miller School of Medicine, Miami, FL, United States
Alberto Pugliese - 0Department of Diabetes Immunology, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA, United States
Alessia Fornoni - Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States
Alessia Fornoni - Peggy and Harold Katz Family Drug Discovery Center, Department of Medicine, University of Miami - Miller School of Medicine, Miami, FL, United States
Publication Details: Frontiers in immunology, Vol.15
Publisher: Frontiers Media S.A
Academic Unit: UMMG Dept of Surgery - Div of General Surgery; UMMG Department of Surgery; Miller School of Medicine; Peggy and Harold Katz Family Drug Discovery Center; UMMG Dept of Medicine - Nephrology & Hypertension Div; UMMG Department of Medicine; UMMG Dept of Medicine - Endocrinology, Diabetes & Metabolism; Diabetes Research Institute (DRI); UMMG Dept of Pediatrics - Nephrology; UMMG Dept of Surgery - Div of Kidney & Pancreas Transplantation; Miami Transplant Institute; UMMG Department of Pediatrics
Language: English
Resource Type: Journal article
Record Identifier: 991032007790002976