Unusual immunophenotypic variant of large B-cell lymphoma associated with HHV-8 and EBV in an HIV positive patient

Roberto Ruiz-Cordero; Jenna Lewis; Clifford Blieden; German Campuzano-Zuluaga; Jose Hernandez; Izidore S Lossos; Francis Ikpatt; Jennifer R Chapman; Francisco Vega

doi:10.1016/j.ehpc.2015.02.002

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Unusual immunophenotypic variant of large B-cell lymphoma associated with HHV-8 and EBV in an HIV positive patient

Journal article

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Unusual immunophenotypic variant of large B-cell lymphoma associated with HHV-8 and EBV in an HIV positive patient

Roberto Ruiz-Cordero, Jenna Lewis, Clifford Blieden, German Campuzano-Zuluaga, Jose Hernandez, Izidore S Lossos, Francis Ikpatt, Jennifer R Chapman and Francisco Vega

Human pathology : case reports, Vol.2(2), pp.49-54

2015-06

DOI: https://doi.org/10.1016/j.ehpc.2015.02.002

Abstract

Kaposi sarcoma-associated herpesvirus

Human herpesvirus type 8

Primary effusion lymphoma

Epstein–Barr virus

Human herpesvirus type 8, also known as Kaposi's sarcoma-associated herpesvirus (HHV-8/KSHV) has been associated with several lymphoproliferative disorders including Kaposi's sarcoma, primary effusion lymphoma (PEL), cases of multicentric Castleman's disease (MCD) including plasmablastic lymphoma associated with MCD, and germinotropic lymphoproliferative disorder. These lymphoproliferative disorders, with the exception of the latter, usually arise in HIV-positive or profoundly immunosuppressed patients. Herein, we describe an unusual large B-cell lymphoma in a 43year-old male infected with HIV who presented with multiple lymphadenopathies. The tumor cells were positive for EBV, HHV-8/KSHV, CD20 (small subset), PAX5, and IgM and negative for CD138, and IgG. This lymphoma is difficult to classify following the 2008 WHO criteria and expands the current spectrum of viral-associated lymphomas.

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Title: Unusual immunophenotypic variant of large B-cell lymphoma associated with HHV-8 and EBV in an HIV positive patient
Creators: Roberto Ruiz-Cordero - Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Jenna Lewis - Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Clifford Blieden - Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
German Campuzano-Zuluaga - Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Jose Hernandez - Department of Pathology at the Mercy Hospital, Miami, FL 33136
Izidore S Lossos - Division of Hematology-Oncology, Department of Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Francis Ikpatt - Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Jennifer R Chapman - Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Francisco Vega - Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136
Publication Details: Human pathology : case reports, Vol.2(2), pp.49-54
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Department of Pathology; UMMG Dept of Medicine - Hematology/Oncology
Language: English
Resource Type: Journal article
Record Identifier: 991031577572502976