Use of Changes in Plasma Levels of Human Immunodeficiency Virus Type 1 RNA to Assess the Clinical Benefit of Antiretroviral Therapy

Ian C Marschner; Ann C Collier; Robert W Coombs; Richard T D'Aquila; Victor DeGruttola; Margaret A Fischl; Scott M Hammer; Michael D Hughes; Victoria A Johnson; David A Katzenstein; Douglas D Richman; Laura M Smeaton; Stephen A Spector; Michael S Saag

doi:10.1086/513823

Back

Use of Changes in Plasma Levels of Human Immunodeficiency Virus Type 1 RNA to Assess the Clinical Benefit of Antiretroviral Therapy

Journal article

Peer reviewed

Use of Changes in Plasma Levels of Human Immunodeficiency Virus Type 1 RNA to Assess the Clinical Benefit of Antiretroviral Therapy

Ian C Marschner, Ann C Collier, Robert W Coombs, Richard T D'Aquila, Victor DeGruttola, Margaret A Fischl, Scott M Hammer, Michael D Hughes, Victoria A Johnson, David A Katzenstein, …

The Journal of infectious diseases, Vol.177(1), pp.40-47

1998-01

DOI: https://doi.org/10.1086/513823

PMID: 9419168

Abstract

Data from 1330 human immunodeficiency virus type 1 (HIV-1)-infected patients enrolled in seven antiretroviral treatment trials were analyzed to characterize the clinical benefit of treatment-mediated reductions in plasma HIV-1 RNA levels. The risk of a new AIDS-defining event or death was reduced proportionally to the magnitude of the reduction of the HIV-1 RNA level during the first 6 months of therapy. Pretherapy HIV-1 RNA levels were prognostic independently of ontherapy levels. In addition, the reduction in risk associated with any given reduction of the level of HIV-1 RNA did not vary by pretherapy level. Having either a reduction in HIV-1 RNA level or an increase in CD4+ lymphocyte count, or both, was associated with a delay in clinical disease progression. This indicates that patient prognosis should be assessed using both HIV-1 RNA and CD4+ lymphocyte responses to therapy.

Metrics

7 Record Views

180 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology
ESI research areas: Immunology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Use of Changes in Plasma Levels of Human Immunodeficiency Virus Type 1 RNA to Assess the Clinical Benefit of Antiretroviral Therapy
Creators: Ian C Marschner - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Ann C Collier - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Robert W Coombs - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Richard T D'Aquila - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Victor DeGruttola - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Margaret A Fischl - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Scott M Hammer - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Michael D Hughes - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Victoria A Johnson - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
David A Katzenstein - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Douglas D Richman - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Laura M Smeaton - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Stephen A Spector - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Michael S Saag - Center for Biostatistics in AIDS Research and Department of Biostatistics, Harvard School of Public Health, Infectious Disease Unit and AIDS Research Center, Massachusetts General Hospital and Harvard School of Medicine, and Division of Infectious Diseases, New England Deaconess Hospital, Boston, Massachusetts, Seattle, Washington, Miami, Florida, London, United Kingdom, Birmingham, Alabama, Stanford, San Diego, California
Publication Details: The Journal of infectious diseases, Vol.177(1), pp.40-47
Publisher: The University of Chicago Press
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Infectious Diseases; UMMG Dept of Psychiatry & Behavioral Sciences
Language: English
Resource Type: Journal article
PMID: 9419168
Record Identifier: 991031600934102976