Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239

Nancy A Wilson; Jason Reed; Gnankang S Napoe; Shari Piaskowski; Andy Szymanski; Jessica Furlott; Edna J Gonzalez; Levi J Yant; Nicholas J Maness; Gemma E May; Taeko Soma; Matthew R Reynolds; Eva Rakasz; Richard Rudersdorf; Adrian B McDermott; David H O'Connor; Thomas C Friedrich; David B Allison; Amit Patki; Louis J Picker; Dennis R Burton; Jing Lin; Lingyi Huang; Deepa Patel; Gwendolyn Heindecker; Jiang Fan; Michael Citron; Melanie Horton; Fubao Wang; Xiaoping Liang; John W Shiver; Danilo R Casimiro; David I Watkins

doi:10.1128/JVI.00171-06

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Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239

Journal article

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Peer reviewed

Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239

Nancy A Wilson, Jason Reed, Gnankang S Napoe, Shari Piaskowski, Andy Szymanski, Jessica Furlott, Edna J Gonzalez, Levi J Yant, Nicholas J Maness, Gemma E May, …

Journal of virology, Vol.80(12), pp.5875-5885

2006-06

DOI: https://doi.org/10.1128/JVI.00171-06

PMCID: PMC1472612

PMID: 16731926

Abstract

Vaccines and Antiviral Agents

The goal of an AIDS vaccine regimen designed to induce cellular immune responses should be to reduce the viral set point and preserve memory CD4 lymphocytes. Here we investigated whether vaccine-induced cellular immunity in the absence of any Env-specific antibodies can control viral replication following multiple low-dose challenges with the highly pathogenic SIVmac239 isolate. Eight Mamu - A * 01 -positive Indian rhesus macaques were vaccinated with simian immunodeficiency virus (SIV) gag , tat , rev , and nef using a DNA prime-adenovirus boost strategy. Peak viremia ( P = 0.007) and the chronic phase set point ( P = 0.0192) were significantly decreased in the vaccinated cohort, out to 1 year postinfection. Loss of CD4 + memory populations was also ameliorated in vaccinated animals. Interestingly, only one of the eight vaccinees developed Env-specific neutralizing antibodies after infection. The control observed was significantly improved over that observed in animals vaccinated with SIV gag only. Vaccine-induced cellular immune responses can, therefore, exert a measure of control over replication of the AIDS virus in the complete absence of neutralizing antibody and give us hope that a vaccine designed to induce cellular immune responses might control viral replication.

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Collaboration types: Industry collaboration; Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Virology
ESI research areas: Microbiology

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Title: Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239
Creators: Nancy A Wilson - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Jason Reed - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Gnankang S Napoe - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Shari Piaskowski - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Andy Szymanski - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Jessica Furlott - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Edna J Gonzalez - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Levi J Yant - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Nicholas J Maness - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Gemma E May - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Taeko Soma - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Matthew R Reynolds - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Eva Rakasz - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Richard Rudersdorf - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Adrian B McDermott - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
David H O'Connor - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Thomas C Friedrich - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
David B Allison - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Amit Patki - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Louis J Picker - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Dennis R Burton - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Jing Lin - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Lingyi Huang - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Deepa Patel - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Gwendolyn Heindecker - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Jiang Fan - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Michael Citron - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Melanie Horton - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Fubao Wang - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Xiaoping Liang - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
John W Shiver - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Danilo R Casimiro - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
David I Watkins - Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53711
Publication Details: Journal of virology, Vol.80(12), pp.5875-5885
Publisher: American Society for Microbiology
Academic Unit: UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 16731926
PMCID: PMC1472612
Record Identifier: 991031598993402976