Virology under the Microscope-a Call for Rational Discourse

Felicia Goodrum; Anice Lowen; Seema Lakdawala; James Alwine; Arturo Casadevall; Michael Imperiale; Walter Atwood; Daphne Avgousti; Joel Baines; Bruce Banfield; Lawrence Banks; Sumita Bhaduri-McIntosh; Deepta Bhattacharya; Daniel Blanco-Melo; David Bloom; Adrianus Boon; Steeve Boulant; Curtis Brandt; Andrew Broadbent; Christopher Brooke; Craig Cameron; Samuel Campos; Patrizia Caposio; Gary Chan; Anna Cliffe; John Coffin; Kathleen Collins; Blossom Damania; Michael Daugherty; Kari Debbink; James DeCaprio; Terence Dermody; Jimmy Dikeakos; Daniel DiMaio; Rhoel Dinglasan; W. Paul Duprex; Rebecca Dutch; Nels Elde; Michael Emerman; Lynn Enquist; Bentley Fane; Ana Fernandez-Sesma; Michelle Flenniken; Lori Frappier; Matthew Frieman; Klaus Frueh; Michaela Gack; Marta Gaglia; Tom Gallagher; Denise Galloway; Adolfo Garcia-Sastre; Adam Geballe; Britt Glaunsinger; Stephen Goff; Alexander Greninger; Meaghan Hancock; Eva Harris; Nicholas Heaton; Mark Heise; Ekaterina Heldwein; Brenda Hogue; Stacy Horner; Edward Hutchinson; Joseph Hyser; William Jackson; Robert Kalejta; Jeremy Kamil; Stephanie Karst; Frank Kirchhoff; David Knipe; Timothy Kowalik; Michael Lagunoff; Laimonis Laimins; Ryan Langlois; Adam Lauring; Benhur Lee; David Leib; Shan-Lu Liu; Richard Longnecker; Carolina Lopez; Micah Luftig; Jennifer Lund; Balaji Manicassamy; Grant McFadden; Michael McIntosh; Andrew Mehle; W. Allen Miller; Ian Mohr; Cary Moody; Nathaniel Moorman; Anne Moscona; Bryan Mounce; Joshua Munger; Karl Muenger; Eain Murphy; Mojgan Naghavi; Jay Nelson; Christopher Neufeldt; Janko Nikolich; Christine O'Connor

doi:10.1128/mbio.00188-23

Back

Virology under the Microscope-a Call for Rational Discourse

Journal article

Peer reviewed

Virology under the Microscope-a Call for Rational Discourse

Felicia Goodrum, Anice Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael Imperiale, Walter Atwood, Daphne Avgousti, Joel Baines, Bruce Banfield, …

mBio, Vol.14(1), p.e0018823

2023-02-28

DOI: https://doi.org/10.1128/mbio.00188-23

PMID: 36700642

Appears in Miller School of Medicine - Latest Publications

Abstract

Life Sciences & Biomedicine

Microbiology

Science & Technology

Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of individuals has seized upon these concerns - conflating legitimate questions about safely conducting virus-related research with uncertainties over the origins of SARS-CoV-2. The result has fueled public confusion and, in many instances, ill-informed condemnation of virology. With this article, we seek to promote a return to rational discourse. We explain the use of gain-of-function approaches in science, discuss the possible origins of SARS-CoV-2 and outline current regulatory structures that provide oversight for virological research in the United States. By offering our expertise, we - a broad group of working virologists - seek to aid policy makers in navigating these controversial issues. Balanced, evidence-based discourse is essential to addressing public concern while maintaining and expanding much-needed research in virology.

Files and links (1)

url

https://doi.org/10.1128/mbio.00188-23View

Published (Version of record) Open

Metrics

1 Record Views

See more details

Details

Title: Virology under the Microscope-a Call for Rational Discourse
Creators: Felicia Goodrum - University of Arizona
Anice Lowen - Emory University
Seema Lakdawala - Emory University
James Alwine - University of Arizona
Arturo Casadevall - Johns Hopkins University
Michael Imperiale - University of Michigan
Walter Atwood - Brown University
Daphne Avgousti - Fred Hutch Cancer Center
Joel Baines - Cornell University
Bruce Banfield - Queen's University
Lawrence Banks - International Centre for Genetic Engineering and Biotechnology
Sumita Bhaduri-McIntosh - University of Florida
Deepta Bhattacharya - University of Arizona
Daniel Blanco-Melo - Fred Hutch Cancer Center
David Bloom - University of Florida
Adrianus Boon - University of Illinois Urbana-Champaign
Steeve Boulant - University of Florida
Curtis Brandt - University of Wisconsin–Madison
Andrew Broadbent - University of Maryland, College Park
Christopher Brooke - University of Illinois Urbana-Champaign
Craig Cameron - University of North Carolina at Chapel Hill
Samuel Campos - University of Arizona
Patrizia Caposio - Oregon Health & Science University
Gary Chan - SUNY Upstate Medical University
Anna Cliffe - University of Virginia
John Coffin - Tufts University
Kathleen Collins - University of Michigan
Blossom Damania - University of North Carolina at Chapel Hill
Michael Daugherty - Univ Calif San Diego, San Diego, CA 92103 USA
Kari Debbink - Johns Hopkins University
James DeCaprio - Harvard University
Terence Dermody - University of Pittsburgh
Jimmy Dikeakos - Western University
Daniel DiMaio - Yale University
Rhoel Dinglasan - University of Florida
W. Paul Duprex - University of Pittsburgh
Rebecca Dutch - University of Kentucky
Nels Elde - University of Utah
Michael Emerman - Fred Hutch Cancer Center
Lynn Enquist - Princeton University
Bentley Fane - University of Arizona
Ana Fernandez-Sesma - Icahn School of Medicine at Mount Sinai
Michelle Flenniken - Montana State University
Lori Frappier - University of Toronto
Matthew Frieman - University of Maryland, College Park
Klaus Frueh - Oregon Health & Science University
Michaela Gack - Vaccine & Gene Therapy Institute of Florida
Marta Gaglia - University of Wisconsin–Madison
Tom Gallagher - Loyola University Chicago
Denise Galloway - Fred Hutch Cancer Center
Adolfo Garcia-Sastre - Icahn School of Medicine at Mount Sinai
Adam Geballe - Fred Hutch Cancer Center
Britt Glaunsinger - University of California, Berkeley
Stephen Goff - Columbia University
Alexander Greninger - University of Washington
Meaghan Hancock - Oregon Health & Science University
Eva Harris - University of California, Berkeley
Nicholas Heaton - Duke University
Mark Heise - University of North Carolina at Chapel Hill
Ekaterina Heldwein - Tufts University
Brenda Hogue - Arizona State University
Stacy Horner - Duke University
Edward Hutchinson - University of Glasgow
Joseph Hyser - Baylor University
William Jackson - Arizona State University
Robert Kalejta - Duke University
Jeremy Kamil - Louisiana State University in Shreveport
Stephanie Karst - University of Florida
Frank Kirchhoff - Universität Ulm
David Knipe - Harvard University
Timothy Kowalik - University of Massachusetts Chan Medical School
Michael Lagunoff - University of Washington
Laimonis Laimins - Northwestern University
Ryan Langlois - University of Minnesota
Adam Lauring - University of Michigan
Benhur Lee - Icahn School of Medicine at Mount Sinai
David Leib - Dartmouth College
Shan-Lu Liu - The Ohio State University
Richard Longnecker - Northwestern University
Carolina Lopez - Washington University in St. Louis
Micah Luftig - Duke University
Jennifer Lund - Fred Hutch Cancer Center
Balaji Manicassamy - University of Iowa
Grant McFadden - Arizona State University
Michael McIntosh - University of Florida
Andrew Mehle - University of Wisconsin–Madison
W. Allen Miller - Iowa State University
Ian Mohr - New York University
Cary Moody - University of North Carolina at Chapel Hill
Nathaniel Moorman - University of North Carolina at Chapel Hill
Anne Moscona - Columbia University
Bryan Mounce - Loyola University Chicago
Joshua Munger - University of Rochester
Karl Muenger - Tufts University
Eain Murphy - SUNY Upstate Medical University
Mojgan Naghavi - Northwestern University
Jay Nelson - Oregon Health & Science University
Christopher Neufeldt - Emory University
Janko Nikolich - University of Arizona
Christine O'Connor - Cleveland Clin, Cleveland, OH USA
Publication Details: mBio, Vol.14(1), p.e0018823
Publisher: Amer Soc Microbiology
Number of pages: 11
Grant note: NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Zoetis LLC University of Florida KS Australian government Cornell University Howard Hughes Medical Institute Medical Research Council, UK; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Flu Lab BB/X011143/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) German research foundation (DFG); German Research Foundation (DFG) Novavax
Academic Unit: Miller School of Medicine; Molecular and Cellular Pharmacology Research
Language: English
Resource Type: Journal article
PMID: 36700642
Record Identifier: 991032796000602976