Where long noncoding RNAs meet DNA methylation

Fan Lai; Ramin Shiekhattar

doi:10.1038/cr.2014.13

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Where long noncoding RNAs meet DNA methylation

Journal article

Open access

Peer reviewed

Where long noncoding RNAs meet DNA methylation

Fan Lai and Ramin Shiekhattar

Cell research, Vol.24(3), pp.263-264

2014-03

DOI: https://doi.org/10.1038/cr.2014.13

PMCID: PMC3945889

PMID: 24481530

Abstract

Research Highlight

DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA ) that is critical for regulation of DNA methylation at this site through the association of ecCEBPA with DNA methyltransferase 1, DNMT1.

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Citation topics: 1 Clinical & Life Sciences; 1.196 Micro & Long Noncoding RNA; 1.196.921 lncRNA
Web Of Science research areas: Cell Biology
ESI research areas: Molecular Biology & Genetics

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Details

Title: Where long noncoding RNAs meet DNA methylation
Creators: Fan Lai - , Philadelphia, PA 19104
Ramin Shiekhattar - , Philadelphia, PA 19104
Publication Details: Cell research, Vol.24(3), pp.263-264
Publisher: Nature Publishing Group
Academic Unit: Miller School of Medicine; UMMG Dept of Human Genetics - Clinical and Translational Genetics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 24481530
PMCID: PMC3945889
Record Identifier: 991031561779902976