White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim; Gakyung Kim; Yoshinari Abe; Pino Alonso; Stephanie Ameis; Alan Anticevic; Paul D Arnold; Srinivas Balachander; Nerisa Banaj; Nuria Bargalló; Marcelo C Batistuzzo; Francesco Benedetti; Sara Bertolín; Jan Carl Beucke; Irene Bollettini; Silvia Brem; Brian P Brennan; Jan K Buitelaar; Rosa Calvo; Miguel Castelo-Branco; Yuqi Cheng; Ritu Bhusal Chhatkuli; Valentina Ciullo; Ana Coelho; Beatriz Couto; Sara Dallaspezia; Benjamin A Ely; Sónia Ferreira; Martine Fontaine; Jean-Paul Fouche; Rachael Grazioplene; Patricia Gruner; Kristen Hagen; Bjarne Hansen; Gregory L Hanna; Yoshiyuki Hirano; Marcelo Q Höxter; Morgan Hough; Hao Hu; Chaim Huyser; Toshikazu Ikuta; Neda Jahanshad; Anthony James; Fern Jaspers-Fayer; Selina Kasprzak; Norbert Kathmann; Christian Kaufmann; Minah Kim; Kathrin Koch; Gerd Kvale; Jun Soo Kwon; Luisa Lazaro; Junhee Lee; Christine Lochner; Jin Lu; Daniela Rodriguez Manrique; Ignacio Martínez-Zalacaín; Yoshitada Masuda; Koji Matsumoto; Maria Paula Maziero; Jose M Menchón; Luciano Minuzzi; Pedro Silva Moreira; Pedro Morgado; Janardhanan C Narayanaswamy; Jin Narumoto; Ana E Ortiz; Junko Ota; Jose C Pariente; Chris Perriello; Maria Picó-Pérez; Christopher Pittenger; Sara Poletti; Eva Real; Y C Janardhan Reddy; Daan van Rooij; Yuki Sakai; João Ricardo Sato; Cinto Segalas; Roseli G Shavitt; Zonglin Shen; Eiji Shimizu; Venkataram Shivakumar; Noam Soreni; Carles Soriano-Mas; Nuno Sousa; Mafalda Machado Sousa; Gianfranco Spalletta; Emily R Stern; S Evelyn Stewart; Philip R Szeszko; Rajat Thomas; Sophia I Thomopoulos; Daniela Vecchio; Ganesan Venkatasubramanian; Chris Vriend; Susanne Walitza; Zhen Wang; Anri Watanabe; Lidewij Wolters; ENIGMA-OCD Working Group

doi:10.1038/s41380-023-02392-6

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White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Journal article

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White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso, Stephanie Ameis, Alan Anticevic, Paul D Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargalló, …

Molecular psychiatry, Vol.29(4), pp.1063-1074

2024-04

DOI: https://doi.org/10.1038/s41380-023-02392-6

PMID: 38326559

Appears in Miller School of Medicine - Latest Publications

Abstract

Adolescent

Adult

Brain - diagnostic imaging

Brain - pathology

Child

Diffusion Tensor Imaging - methods

Female

Humans

Machine Learning

Male

Middle Aged

Obsessive-Compulsive Disorder

White Matter - diagnostic imaging

White Matter - pathology

Young Adult

White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group. We used an automatic machine learning pipeline (with feature engineering and selection, and model optimization) and examined the cross-site generalizability of the OCD classification models using leave-one-site-out cross-validation. Our models showed low-to-moderate accuracy in classifying (1) "OCD vs. healthy controls" (Adults, receiver operator characteristic-area under the curve = 57.19 ± 3.47 in the replication set; Children, 59.8 ± 7.39), (2) "unmedicated OCD vs. healthy controls" (Adults, 62.67 ± 3.84; Children, 48.51 ± 10.14), and (3) "medicated OCD vs. unmedicated OCD" (Adults, 76.72 ± 3.97; Children, 72.45 ± 8.87). There was significant site variability in model performance (cross-validated ROC AUC ranges 51.6-79.1 in adults; 35.9-63.2 in children). Machine learning interpretation showed that diffusivity measures of the corpus callosum, internal capsule, and posterior thalamic radiation contributed to the classification of OCD from HC. The classification performance appeared greater than the model trained on grey matter morphometry in the prior ENIGMA OCD study (our study includes subsamples from the morphometry study). Taken together, this study points to the meaningful multivariate patterns of white matter features relevant to the neurobiology of OCD, but with low-to-moderate classification accuracy. The OCD classification performance may be constrained by site variability and medication effects on the white matter integrity, indicating room for improvement for future research.

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Title: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
Creators: Bo-Gyeom Kim - Seoul National University
Gakyung Kim - Seoul National University
Yoshinari Abe - Kyoto Prefectural University of Medicine
Pino Alonso - Bellvitge University Hospital
Stephanie Ameis - Centre for Addiction and Mental Health
Alan Anticevic - Yale University
Paul D Arnold - University of Calgary
Srinivas Balachander - National Institute of Mental Health and Neurosciences
Nerisa Banaj - Fondazione Santa Lucia
Nuria Bargalló - Hospital Clínic de Barcelona
Marcelo C Batistuzzo - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Francesco Benedetti - Vita-Salute San Raffaele University
Sara Bertolín - Bellvitge University Hospital
Jan Carl Beucke - Humboldt-Universität zu Berlin
Irene Bollettini - IRCCS Ospedale San Raffaele
Silvia Brem - University of Zurich
Brian P Brennan - McLean Hospital
Jan K Buitelaar - Radboud University Nijmegen
Rosa Calvo - Universitat de Barcelona
Miguel Castelo-Branco - University of Coimbra
Yuqi Cheng - Kunming Medical University
Ritu Bhusal Chhatkuli - Center for Forensic Mental Health, Chiba University
Valentina Ciullo - Fondazione Santa Lucia
Ana Coelho - University of Minho
Beatriz Couto - University of Minho
Sara Dallaspezia - IRCCS Ospedale San Raffaele
Benjamin A Ely - Albert Einstein College of Medicine
Sónia Ferreira - University of Minho
Martine Fontaine - Columbia University
Jean-Paul Fouche - Genomics
Rachael Grazioplene - Yale University
Patricia Gruner - Yale University
Kristen Hagen - Molde Hospital
Bjarne Hansen - Haukeland University Hospital
Gregory L Hanna - University of Michigan
Yoshiyuki Hirano - Center for Forensic Mental Health, Chiba University
Marcelo Q Höxter - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Morgan Hough - Warneford Hospital
Hao Hu - Shanghai Mental Health Center
Chaim Huyser - Amsterdam University Medical Centers
Toshikazu Ikuta - University of Mississippi
Neda Jahanshad - University of Southern California
Anthony James - University of Oxford
Fern Jaspers-Fayer - University of British Columbia
Selina Kasprzak - Amsterdam Neuroscience
Norbert Kathmann - Humboldt-Universität zu Berlin
Christian Kaufmann - Humboldt-Universität zu Berlin
Minah Kim - Seoul National University Hospital
Kathrin Koch - Technical University of Munich
Gerd Kvale - Haukeland University Hospital
Jun Soo Kwon - Seoul National University
Luisa Lazaro - Centro de Investigación Biomédica en Red de Salud Mental
Junhee Lee - Seoul National University Hospital
Christine Lochner - Stellenbosch University
Jin Lu - Kunming Medical University
Daniela Rodriguez Manrique - Klinikum rechts der Isar
Ignacio Martínez-Zalacaín - Bellvitge University Hospital
Yoshitada Masuda - Chiba University Hospital
Koji Matsumoto - Chiba University Hospital
Maria Paula Maziero - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Jose M Menchón - Universitat de Barcelona
Luciano Minuzzi - St. Joseph’s Healthcare Hamilton
Pedro Silva Moreira - University of Minho
Pedro Morgado - University of Minho
Janardhanan C Narayanaswamy - National Institute of Mental Health and Neurosciences
Jin Narumoto - Kyoto Prefectural University of Medicine
Ana E Ortiz - Hospital Universitari de Vic
Junko Ota - Center for Forensic Mental Health, Chiba University
Jose C Pariente - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Chris Perriello - University of Illinois Urbana-Champaign
Maria Picó-Pérez - University of Minho
Christopher Pittenger - Yale University
Sara Poletti - IRCCS Ospedale San Raffaele
Eva Real - Universitat de Barcelona
Y C Janardhan Reddy - National Institute of Mental Health and Neurosciences
Daan van Rooij - Radboud University Nijmegen
Yuki Sakai - Kyoto Prefectural University of Medicine
João Ricardo Sato - Universidade Federal do ABC
Cinto Segalas - Universitat de Barcelona
Roseli G Shavitt - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Zonglin Shen - Kunming Medical University
Eiji Shimizu - Center for Forensic Mental Health, Chiba University
Venkataram Shivakumar - National Institute of Mental Health and Neurosciences
Noam Soreni - Offord Centre for Child Studies, Hamilton, Ontario, Canada
Carles Soriano-Mas - Universitat de Barcelona
Nuno Sousa - University of Minho
Mafalda Machado Sousa - University of Minho
Gianfranco Spalletta - Fondazione Santa Lucia
Emily R Stern - New York University
S Evelyn Stewart - University of British Columbia
Philip R Szeszko - Icahn School of Medicine at Mount Sinai
Rajat Thomas - Weill Cornell Medical College in Qatar
Sophia I Thomopoulos - University of Southern California
Daniela Vecchio - Fondazione Santa Lucia
Ganesan Venkatasubramanian - National Institute of Mental Health and Neurosciences
Chris Vriend - Amsterdam Neuroscience
Susanne Walitza - University of Zurich
Zhen Wang - Shanghai Mental Health Center
Anri Watanabe - Kyoto Prefectural University of Medicine
Lidewij Wolters - Norwegian University of Science and Technology
ENIGMA-OCD Working Group
Publication Details: Molecular psychiatry, Vol.29(4), pp.1063-1074
Grant note: JP22dm0307002 / Japan Agency for Medical Research and Development (AMED) Wellcome Trust K01 MH122774 / NIMH NIH HHS K23 MH115206 / NIMH NIH HHS 22H01090, 19K03309 / MEXT | Japan Society for the Promotion of Science (JSPS) K24MH121571 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) UL1 TR001863 / NCATS NIH HHS P41 EB015922 / NIBIB NIH HHS JP22dm0307008 / Japan Agency for Medical Research and Development (AMED) R01 MH116147 / NIMH NIH HHS
Academic Unit: Miller School of Medicine; UMMG Dept of Psychiatry & Behavioral Sciences
Language: English
Resource Type: Journal article
PMID: 38326559
Record Identifier: 991032796063402976