Abstract
In this issue of Molecular Cell, Xiang et al.
provided insights into the mechanism and structure-guided engineering of DdCBE for mitochondrial DNA base editing. More precise editing was achieved by better defining the editing window.
- Title
- mtDNA base editing: Mind the gap
- Creators
- Jose Domingo Barrera-Paez - University of CambridgeCarlos T Moraes - University of Miami
- Publication Details
- Molecular cell, Vol.85(18), p.3351
- Publisher
- CELL PRESS; CAMBRIDGE
- Number of pages
- 2
- Grant note
- UKRI Medical Research Council UK (MRC): MC_UU_ 00028/3 AFM-Telethon: 24237 Comini Foundation (MitoFight2)National Institutes of Health (NIH): R01EY010804 Army Research Office: W911NF2510210 Muscular Dystrophy Association (MDA): 964119 Research to Prevent Blindness Stein AwardFlorida Department of Health: 25K09, 25R01 POLG Foundation
J.D.B.-P. is supported by core funding from UKRI Medical Research Council UK (MRC) (MC_UU_ 00028/3), AFM-Telethon (24237), and a research grant from the Comini Foundation (MitoFight2) to M. Minczuk. C.T.M. is supported by the National Institutes of Health (NIH) award R01EY010804, the Army Research Office (W911NF2510210), the Muscular Dystrophy Association (MDA 964119), the Research to Prevent Blindness Stein Award, the Florida Department of Health (25K09 and 25R01), and The POLG Foundation.
- Academic Unit
- Miller School of Medicine; UMMG Department of Neurology
- Language
- English
- Resource Type
- Journal article
- PMID
- 40972522
- Record Identifier
- 991032798689502976