p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

We thank Dr. Andrew Olson (Stanford Neuroscience Microscopy Service, supported by National Institutes of Health [NIH] grant NS069375). M.M.-N. is supported by an EMBO long-term fellowship (ALTF 301-2017), the SSSI-Muscular Dystrophy Association (M.M.-N.), and Stanford School of Medicine Dean's postdoctoral fellowships (M.M.-N.). This work was supported by NIH grants R35NS097263(10) (A.D.G.), R01NS094239 (T.E.L.), R01NS101986 (F.-B.G.), R37NS057553 (F.-B.G.), R35NS097273(17) (L.P.), P01NS084974 (L.P.), P01NS099114 (L.P.), R01NS089786 (M.T.L.), 1F32MH114620 (G.R.), K01AG049152 (J.S.Y.), R35CA197591 (L.D.A.), R01MH109912 (D.H.G.), R01NS097850 (J.K.I.), R01NS097850-01S1 (R.L.-G.), P50HG007735 (W.J.G.), R01HG008140 (W.J.G.), U19AI057266 (W.J.G.), UM1HG009442 (W.J.G.), and 1UM1HG009436 (W.J.G.); the Robert Packard Center for ALS Research at Johns Hopkins (A.D.G.); Target ALS (A.D.G., F.-B.G., J.C., L.P., and T.E.L.); the Blavatnik Family Foundation (J.A.B.); the Alzheimer's Association (2018-AARFD-592264 to G.R.L.); the Brain Rejuvenation Project of the Wu Tsai Neurosciences Institute (A.D.G.); the U.S. Department of Defense (grant W81XWH-15-1-0187 to J.K.I.); the Merkin Family Foundation (J.K.I.); the New York Stem Cell Foundation (J.K.I.); the John Douglas French Alzheimer's Foundation; and the Tau Consortium (J.K.I.). J.K.I. is a New York Stem Cell Foundation Robertson Investigator and a Richard N. Merkin Scholar. W.J.G. is a Chan Zuckerberg Biohub investigator. Some of the computing for this project was performed on the Sherlock cluster. We would like to thank Stanford University and the Stanford Research Computing Center for providing computational resources and support that contributed to these research results. This work used the Genome Sequencing Service Center by Stanford Center for Genomics and Personalized Medicine Sequencing Center, supported by NIH grant S10OD020141. Some of the figures were created with BioRender.com.