Abstract
The activities of the gelatinases MMP-2 and MMP-9 were evaluated with gel and in situ zymography to assess possible gelatinase modulation after vessel targeting therapy with anecortave acetate (AA), an antiangiogenic drug, in LHBETATAG retinal tumors. In the present study, gelatinase activity decreased after treatment with AA and correlated with a significant decrease in tumor burden. Gelatinase activity may be a useful adjuvant strategy to target retinoblastoma.