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Increased APOEε4 expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgrounds
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Increased APOEε4 expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgrounds

A. J Griswold, K Celis, P Bussies, F Rajabli, P Whitehead, K Hamilton-Nelson, G. W Beecham, D. M Dykxhoorn, K Nuytemans, L Wang, …
Cold Spring Harbor Laboratory
2020-03-11
DOI: https://doi.org/10.1101/2020.03.09.983817

Abstract

Abstract APOEε4 African local genomic ancestry (LA) confers less risk for Alzheimer disease (AD) relative to European LA (LA) carriers. Single nucleus RNA sequencing from AD- APOEε4/4 frontal cortex found European LA carriers have a 1.45-fold greater APOEε4 expression (p< 1.8 E10 −313 ) and are associated with a unique A1 reactive astrocyte cluster. This suggests a potential mechanism for the increased risk for AD seen in European LA carriers of APOEε4 .
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https://doi.org/10.1101/2020.03.09.983817View
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