Expertise
Genetic and Molecular Epidemiology:
Recent data have established that the development of human complex disease involves many genetic and epigenetic changes. Loss of genomic integrity, resulting from genetic defects and exposure to environmental agents, plays an important role in complex disease development. However, the mechanisms by which specific molecules, operative in chromatin functions, initiate these pathogenic processes are not well known. Understanding the function of genes involved in genomic integrity, the relation of these genes to disease susceptibility, the role of environmental agents in causing specific genetic changes and the interaction between genes and environmental exposures in the etiology are important areas of biomedical research.
My research interest is in investigating independent and interactive contributions of genetic and environmental factors to human diseases through quantitative genetic and molecular epidemiology with a specific attention towards the role of gene-gene and gene-environment interactions in the development of complex disorders.
Allelic Association, Biomarker, Complex Trait, Cox Model, Familial Cancer, Intergenic and Gene-environment Interaction, Linkage, Logistic/Poission Regression, Multiple Cancer, Polymorphism, Segregation