Expertise
Dr. Serafini’s research interests focus principally on understanding the molecular and cellular pathways myeloid cells, and in particular myeloid derived suppressor cells (MDSC), employed to regulate immune tolerance in physiological status as well as in disease.
Current Research Interests
- Targeting tumor associated myeloid cells in vivo via RNA aptamer to vehicle chemotherapeutic drugs and therapeutic RNAs
- Determining the role of chemokine receptors in myeloid cell polarization in tumor hosts
- Evaluating the synergy of PDE5 inhibitors and anti-tumor vaccine in patients with HNSCC undergoing salvage surgery.
- Use of MDSCs in Type 1 diabetes to induce long term tolerance
- Use of RNA aptamers to vehicle imaging reagents and therapeutic RNAs to mouse and human islets.
Links
Organizational Affiliations
Education
PhD