Expertise
Chronic morphine and immunosupression
- Molecular and cellular mechanism
- Consequence on wound healing events
- Susceptibility to opportunistic infection
Morphine modulation of Hypoxia induced Hif-1 alpha and consequence in angiogenesis, wound repair and intimal hyperplasia
Opioids are the gold standard for the management of moderate to severe cancer pain. The clinical use of opioids is limited because of co-morbidities associated with extended use. The goal of Dr. Roy’s studies is to identify therapeutic targets that can prolong opioid use and minimize its co-morbidities. Their recent studies show an association between chronic opioid use and altered gut microbiome. These findings have strong implications that manipulating the gut microbiome can be a potential therapeutic target to improve the pain relieving efficacy of opioids.