Expertise
High Content Screening and Functional Genomics of the Nervous System.
Dr. Lemmon is currently involved in informatics projects to describe high throughput screening data; the BioAssay Ontology Project, the LINCS Information FramEwork, and the RegenBase Project
For many years Dr. Lemmon studied development of the nervous system, especially the role of cell adhesion molecules and extracellular matrix molecules.
His lab did extensive work on L1cam signaling and recycling in the context of axon growth.
We use High Content Analysis to test thousands of genes and compounds on various primary neurons in culture to identify those that can promote or inhibit axon growth and regeneration. We use information theory and artificial intelligence approaches to identify targets.
We use RNASeq to uncover mRNAs and miRNAs relevant to axon regeneration. We are especially interested in transcription factors as tools to promote regeneration and use bioinformatic tools to uncover them.
Cancer vaccines; Axon Regeneration; Cell Adhesion Molecules; High Content Imaging, High Content Screening, Light Sheet Fluorescence Microscopy; Ontology Development and Informatics; Vaccine development.