Expertise
Mechanisms of Human DNA Repair, Interstrand Cross-Link Repair and Mismatch Repair.
We are interested in deciphering the molecular mechanism of ICL repair, delineating role of Fanconi anemia proteins in DNA repair, and studying the relationship between Fanconi anemia proteins and human cancers. Our research relies on a biochemically defined reconstitution system and cell-based analyses.
Our research is focused on the molecular mechanisms of DNA repair and mutagenesis that is directly related to cancers and other human diseases.
We are interested in three repair mechanisms that are coupled with DNA replication: interstrand cross-link (ICL) repair, mismatch repair (MMR), and translesion synthesis (TLS).
We are interested in understanding mechanisms of MMR. TLS is a very important DNA damage tolerance mechanism.
1) To determine role of Fanconi anemia proteins in DNA repair and genome instability.
2) To determine role of DNA repair proteins in cancer development.
3) To study whether DNA repair proteins are targetable for cancer treatment.