Study the role of B cell in regulation of anti-tumor response in solid tumor. Identify a subset of the B regulatory cells in the solid tumor and their phenotype and function in suppressing T cell anti-tumor response. In mouse model, B cells upon migration into tumor microenvironment and in contact with tumor cells become suppressor cells like T regulatory cells, we named that subset of B cells as B regulatory cells (Breg cells).
1). B regulatory cells and mechanisms in inhibition of anti-tumor immunity in mouse and human solid tumors. 2). Vasculogeneic mimicry and suppression of the immune response in cancer.