Zhibin Chen

Current Research Interests

• Cross-differentiation of T cell lineages, immune memory and immune tolerance.
• Mechanisms of autoimmunity as a double agent in tumor killing and cancer promotion.
• Mechanisms of tissue repairing and regeneration at the site of immune damage
• Epigenetic dysregulation during aging-associated carcinogenesis
• Tumor transcriptome diversification by alternative splicing

Dr. Chen's laboratory studies immunological mechanisms and interventions of cancer. Their focus is on the double-edged role of autoimmunity and inflammation in cancer development and tumor killing, with a particular interest in age-associated tumorigenesis. They build animal models to mimic the genetic and genomic risks of human cancers, examine the cause and effect in tumorigenesis at molecular, cellular and systems levels, identify potential biomarkers of cancer development, and test potential interventions for cancer prevention and treatment.